You are not alone
Primary immunodeficiency (PI) doesn’t have to feel isolating.
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Understanding primary immunodeficiency (PI)
Understanding PI
The more you understand about primary immunodeficiency (PI), the better you can live with the disease or support others in your life with PI. Learn more about PI, including the various diagnoses and treatment options.
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Living with PI
Living with PI
Living with primary immunodeficiency (PI) can be challenging, but you’re not alone—many people with PI lead full and active lives. With the right support and resources, you can, too.
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Get involved
Get involved
Be a hero for those with PI. Change lives by promoting primary immunodeficiency (PI) awareness and taking action in your community through advocacy, donating, volunteering, or fundraising.
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Advancing research and clinical care
Advancing research and clinical care
Whether you’re a clinician, researcher, or an individual with primary immunodeficiency (PI), IDF has resources to help you advance the field. Get details on surveys, grants, and clinical trials.
Live the best you can today.
“The Immune Deficiency Foundation has had a significantly positive impact on my life,” says Taylor, a Youth Advisory Committee member and 2024 Mary Rath Emerging Leader Award recipient. Help more individuals like Taylor thrive with primary immunodeficiency by giving today.
Get involved
Advocate
Even if you’re new to PI advocacy, there are many ways to raise awareness. We’ll help you get started.
Give
Our resources, services, and outreach are largely funded by donors like you.
Volunteer
Your gift of time makes a difference. IDF always needs peer support participants and event volunteers.
Fundraise
Whether you join the IDF Sustainers Club or start a Facebook fundraiser, all efforts can make a difference.
Host a screening of IDF's new documentary
Witness the impossible decisions faced by those living with primary immunodeficiency (PI) disorders. Host a private screening of Compromised: Life Without Immunity to experience the resilience, hope, and determination of the PI community. And know that your hosted event can be two people or 100+!
2025 Advocacy Day & Young Advocates Academy
Every treatment. Every insurance battle. Every late diagnosis. These aren't just challenges – they're reasons to speak up. Join IDF Advocacy Day and Young Advocates Academy in D.C. April 30-May 1, 2025. All expenses covered.
How well do you know your immune system?
Take our self-assessment to find out if your symptoms could point to a primary immunodeficiency (PI). It’s an informative way to gather insights that you can discuss with your healthcare provider.
Let us guide you.
If you are living with PI, think you might have PI, are a caregiver, a healthcare professional, or are just looking to learn more we can help.
Who is the Immune Deficiency Foundation?
IDF transforms the lives of tens of thousands each year*
822,098
unique visitors to the IDF website to access resources, information, and connection.
3,195
healthcare professionals learned more about PI diagnosis and treatment.
30,320
individuals living with PI received educational resources and support.
*statistics based on 2023 Community Impact Report
Learn and share
Be a plasma hero
The more we learn about plasma, the more we realize its life-saving potential. We need heroes to step up, donate, and save lives.
Promote plasma donation
Types of PI
There are more than 450 primary immunodeficiencies, also known as inborn errors of immunity (IEI).
Explore PI types
Recursos en español
¡Bienvenidos! Para ver nuestros recursos disponibles, haga clic en el siguiente enlace.
Ver los recursos
IDF podcast
Listen to the latest episode of the IDF Podcast, or one of our sub-series Undiagnosed or Bold Conversations.
Listen or subscribe
Videos & recordings
Join IDF on YouTube to help spread awareness and education about PI and tune in to see what is happening.
Watch videos
Immunocompromised Collaborative
Joining forces to protect the most vulnerable against infectious disease.
Learn about the collaborative
Join an IDF event
Learn more about all the ways to learn, connect, and engage with IDF, whether online and in person.
Stay informed
Browse the latest news articles, videos, and podcasts to find the most up-to-date information about advancements in PI treatments, portrayal in the media, and other IDF efforts.
Sign up for updates from IDF
Receive news and helpful resources to your cell phone or inbox. You can change or cancel your subscription at any time.
